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Immune Checkpoint Targets

Identifying & Exploiting Immune Checkpoint Targets for Next Generation Cancer Therapies

Tumors can progress only if they evade the immune system. Many tumors have evolved mechanisms of exploiting cancer-preventing 'checkpoints' in the immune system to their advantage.

Therapeutic antibodies targeting these checkpoints restore anti-tumor immune function allowing the immune system to recognise and kill cancer cells.

OBT leverages detailed mapping of cell surface proteins expressed on cancer cells, normal tissue cells, tumor-infiltrating lymphocytes (TILs) and healthy immune cells to identify molecules involved in tumor-immune cell cross-talk. OBT has identified novel targets and pathways involved in immune surveillance and tumor immune evasion thereby generating a unique insight into the cancer–immune cell interface. OBT is in the process of translating several of these molecules into powerful immune-modulatory therapies targeting multiple immune cells and cancer types.
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 New receptor-ligand immune escape axis escape mechanism
OBT has discovered and characterised a novel cancer immune escape mechanism independent of PD-1/PD-L1 axis. OBT is targeting this novel ligand-receptor immune escape axis with IO therapies in order to reactivate the killer cells of the immune system (CTLs and NK cells) and boost anti-cancer immune response in patients."
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  • ABOUT
    • OUR TEAM
    • BOARD OF DIRECTORS
    • INVESTORS
    • OFFICES & LABS
  • PIPELINES
    • INTERNAL PROGRAMS
    • PARTNERED PROGRAMS
  • PARTNERSHIPS
  • OUR SCIENCE
    • IO DISCOVERY PLATFORM >
      • IMMUNE CHECKPOINT TARGETS
      • IO ANTIBODY ENGINEERING
    • OGAP DISCOVERY PLATFORM
    • PUBLICATIONS
  • CAREERS
  • NEWS
    • PRESS RELEASES
    • OBT in the News
  • CONTACT